Review Articles Review Articles

Review Articles

Chapters

Yutaka Niihara: Shortcomings to sickle cells. In: Japan-North America Medical Exchange Foundation (JANAMEF) eds. A passport for clinical training in the North America; 63-72, 2001.

Niihara Y: Non-immune hemolytic anemia. In: Rakel RE. Bope ET, eds. Conn's Current Therapy. 55th -2003 ed. Philadelphia: W.B. Saunders; 408-411, 2003.

Abstracts

Niihara Y, Zerez CF, Akiyama OS, Tanaka KR: Increased red cell glutamine availability in sickle cell anemia. l. Demonstration of a several fold increase in active glutamine transport in intact red cells. Blood 84:Supp1 1, 404a, 1994.

Zerez CF, Niihara Y, Akiyama DS, Tanaka KR: Increased red cell glutamine availability in sickle cell anemia. II. Evidence for higher affinity red cell glutamine transport and higher plasma glutamine concentration. Blood 84:Suppl 1, 41 1a, 1994.

Niihara Y, Zerez CF, Akiyama DS, Tanaka KR: Increased red cell glutamate in sickle cell disease: Evidence that increased glutamine availability is a mechanism for increased total NAD. Journal of Investigative Medicine 43:Suppl 1, 131a, 1995.

Niihara Y, Zerez CF, Akiyama DS, Tanaka KR: Normalization of redox potential in sickle red blood cells by oral administration of L-glutamine. Blood 86:SuppI 1, 652a, 1995.

Niihara Y, Zerez CR, Akiyama DS, Tanaka KR: Elevation of redox potential in sickle red blood cells by oral administration of L-glutamine. Journal of Investigative Medicine 44;Suppl 1. 109a, 1996.

Niihara Y, Zerez CR, Akiyama DS, Tanaka KR: Oral L-glutamine therapy in sickle cell anemia: Improvement of redox potential and positive subjective clinical response. Journal of Investigative Medicine 44:215a. 1996.

Niihara Y, Zerez CF, Akiyama DS, Tu A, Tanaka KR: Decrease in frequency of painful crises in sickle cell anemia by L-glutamine. Blood 88:Suppl 1, 20b, 1996.

Niihara Y, Zerez CF, Akiyama DS, Tanaka KR: Improvement of redox potential in a sickle cell anemia patient with oral L-glutamine at 10 grams a day. J Invest Med 45:102A, 1997.

Niihara Y, Shen YM, Akiyama DS, Kalra VK, Tanaka KR: Oral L-glutamine therapy for sickle cell anemia: II. Decreased adhesiveness to human umbilical vein endothelial cells. Blood 90:Suppl 1, 29b. 1997.

Niihara Y, Ge J, Shalev O, Hebbel RP, Tanaka KR: Desferal (DFO) incubation of intact red blood cells (RBC) leads to decrease in NAD redox potential: Evidence for desferal as an inducer of oxidant stress in intact RBC. Blood 2:Suppl 1, 7b, 1998.

Niihara Y, Wu H, Tu A, Akiyama DS, Shalev 0, Hebbel RP, Tanaka KR: Desferal (DFO) conjugated with starch decrease NAD redox potential of intact red blood cells (RBC): Evidence for DFO as an extracellular inducer of oxidant stress in RBC. FASEBJ:Volume 13, number 5:part 11, A1038, 1999.

Niihara Y, Matsui NM, Sunga MA, Magpayo J, Embury SH, Tanaka KR, Johnson CS: Oral L-glutamine therapy reduces adherence of sickle red blood cells to human umbilical vein endothelial cells. Blood 96:11, 595a, 2000.

Takasu J, Uykimpang R, Sunga MA, Amagase H, Niihara Y: Aged Garlic Extract therapy for sickle cell anemia patients. Blood 98: 18b-19b, 2001.